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If you’ve added a static route in Ubuntu and want to make sure it stays after a reboot, you can add the following command to your /etc/network/interfaces config file:

post-up /sbin/ip route add 10.4.0.0/16 via 10.4.190.1

This command gets run by the networking daemon at startup and will add the route to your routing table. It’s always best to test static routes manually before adding them to your interfaces config file, like these examples:

route add -net 192.168.1.1 netmask 255.255.255.0 gw 10.0.0.1

route add -host 192.168.21.21 gw 172.16.21.1

If you can then get to that network or that host it works. So modify the post-up command in the interfaces file to suit your needs.